Maritime activity and risk patterns in the High North : MARPART Project Report 2

This report provides a discussion on dominating risk factors, risk types and probability of unwanted incidents in the Arctic region. It also provides a coarse-grained evaluation of the potential consequences of different incidents in the northern sea areas of Russia, Norway, Greenland, and Iceland. The risk assessment build upon statistics on vessel activity, case studies of real incidents, and expert evaluation of defined situations of hazard and accident (DSHA). The evaluations of this study may serve as a platform for more detailed assessments, and as input for discussions on priority areas in respect to safety measures and emergency preparedness. In the Marpart Project, the risk assessments have a special role as input into the analyses of emergency management capabilities, and the need for special government efforts in cross-border cooperation

Maritime activity and risk patterns in the High North : MARPART Project Report 2

This report provides a discussion on dominating risk factors, risk types and probability of unwanted incidents in the Arctic region. It also provides a coarse-grained evaluation of the potential consequences of different incidents in the northern sea areas of Russia, Norway, Greenland, and Iceland. The risk assessment build upon statistics on vessel activity, case studies of real incidents, and expert evaluation of defined situations of hazard and accident (DSHA). The evaluations of this study may serve as a platform for more detailed assessments, and as input for discussions on priority areas in respect to safety measures and emergency preparedness. In the Marpart Project, the risk assessments have a special role as input into the analyses of emergency management capabilities, and the need for special government efforts in cross-border cooperation

The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

The genetic architecture of the small and isolated Greenlandic population is advantageous for identification of novel genetic variants associated with cardio-metabolic traits. We aimed to identify genetic loci associated with body mass index (BMI), to expand the knowledge of the genetic and biological mechanisms underlying obesity. Stage 1 BMI-association analyses were performed in 4,626 Greenlanders. Stage 2 replication and meta-analysis were performed in additional cohorts comprising 1,058 Yup'ik Alaska Native people, and 1,529 Greenlanders. Obesity-related traits were assessed in the stage 1 study population. We identified a common variant on chromosome 11, rs4936356, where the derived G-allele had a frequency of 24% in the stage 1 study population. The derived allele was genome-wide significantly associated with lower BMI (beta (SE), -0.14 SD (0.03), p = 3.2x10-8), corresponding to 0.64 kg/m2 lower BMI per G allele in the stage 1 study population. We observed a similar effect in the Yup'ik cohort (-0.09 SD, p = 0.038), and a non-significant effect in the same direction in the independent Greenlandic stage 2 cohort (-0.03 SD, p = 0.514). The association remained genome-wide significant in meta-analysis of the Arctic cohorts (-0.10 SD (0.02), p = 4.7x10-8). Moreover, the variant was associated with a leaner body type (weight, -1.68 (0.37) kg; waist circumference, -1.52 (0.33) cm; hip circumference, -0.85 (0.24) cm; lean mass, -0.84 (0.19) kg; fat mass and percent, -1.66 (0.33) kg and -1.39 (0.27) %; visceral adipose tissue, -0.30 (0.07) cm; subcutaneous adipose tissue, -0.16 (0.05) cm, all p<0.0002), lower insulin resistance (HOMA-IR, -0.12 (0.04), p = 0.00021), and favorable lipid levels (triglyceride, -0.05 (0.02) mmol/l, p = 0.025; HDL-cholesterol, 0.04 (0.01) mmol/l, p = 0.0015). In conclusion, we identified a novel variant, where the derived G-allele possibly associated with lower BMI in Arctic populations, and as a consequence also leaner body type, lower insulin resistance, and a favorable lipid profile